Background and Objective: Hypertension in patients with non-alcoholic fatty liver disease is the main cause of cardiovascular disease . The present study aimed to determine the effect of Berberis vulgaris fruit extract on blood pressure and weight in patients with non-alcoholic fatty liver disease.

  Material and Methods: This clinical trial was conducted in 2011 on 80 patients with non-alcoholic fatty liver disorder, including 32 males (40%) and 48 females (60%), who were randomly assigned into case and control group. The case group were given two capsules (750 mg) including berberis vulgaris extract every day for three months, while the subjects of control group treated by placebo. Blood pressure and weight of baseline and those of after three month were assessed and analyzed by SPSS software Ver.17, using paired t-test and independent t-test (p≤0.05).

  Results: the mean of weight decreased from 80.23±11.68 (baseline) to 78.71±11.31 (End of the third month), which was statistically significant compared to control group (P<0.001). The Mean of systolic and diastolic blood pressure was significant compared to control group. (p<0.05).

  Conclusion: Considering the significant decrease in weight and blood pressure, further studies with larger sample size are needed to generalize crucially the results. This extract can be introduced to treat overweight and hypertension in patients with non-alcoholic fatty liver disease.

  Background and Objective: The Fatigue related to cancer is one of the common problems of both patients and care-givers. Nowadays, acupressure as a complementary medicine has become more common in patients with cancer for balancing and improving body energy. This study aimed to assess the effect of acupressure on the fatigue of patients with cancer.

  Material and Methods: This blinded- randomized clinical trial was conducted on 85 patients with cancer in hematology ward of Beheshti hospital of Hamadan. The subjects were located in three groups of intervention, sham and control. First, the fatigue level was measured by Brief Fatigue Inventory (BFI) as a baseline. Then, real acupressure in intervention group and unreal acupressure in sham group was performed for 10 days and only routine cares were given in control group. The fatigue amount was measured on the fifth and tenth days. The Data was analyzed by SPSS software version 16, using paired T- test and repeated measurements.

  Results: Acupressure was effective on the fatigue of patients with cancer (p<0.001). However, conducting unreal acupressure in sham group was effective as well (p<0.01), but the routine cares in control group was not effective and even in some cases led to increased fatigue.

  Conclusion: Acupressure can be used as a complementary therapy to decrease the fatigue in the patients with cancer considering its low cost, safety and simplicity.