en Nursing Original Article <div class="WordSection1"><span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times=""> Despite the expansion of knowledge of neonatal pain assessment and management, there is still a considerable gap between nurses&#39; clinical practices in Iran and available evidence. The aim of this study was to develop an evidence-based protocol for neonatal pain management and to evaluate its effectiveness on nurses&#39; clinical practice.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times=""> The present study will be based on the Johns Hopkins nursing evidence-based practice (JHNEBP) model and the three stages of practice question and project planning, evidence, and translation (PET). In this way, after forming an interprofessional team, clinical practice questions will be defined, and the main stakeholders will be identified. Then, the types, levels, and quality of evidence will be assessed to summarize their final strength using the proposed tools of the model, and finally, recommendations will be developed. In the translation phase, the recommendations will be implemented during a stepped wedge cluster randomized trial, and its implications for nursing practices in the management of pain in hospitalized neonates will be evaluated.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times=""> The results of this study will lead to the production of an operational and applicable protocol in the management of pain in hospitalized neonates. It can provide the basis for improving the clinical practice of nurses and subsequently improving the quality of neonatal care. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:8.0pt"><span new="" roman="" style="font-family:" times=""> One of the strengths of this study is the use of an interprofessional team approach, considering the clients&#39; priorities, and the improvement of organizational culture in order to endeavor for knowledge translation and change in clinical practice.</span></span></span></span></span><br> &nbsp;</div> <div dir="rtl"><div aria-label="Page Break" class="cke_pagebreak" contenteditable="false" data-cke-display-name="pagebreak" data-cke-pagebreak="1" style="page-break-after:always" title="Page Break"></div></div> Evidence-Based Practice, Pain Management, Neonates, Protocol, Nursing Care 64 68 http://nmj.goums.ac.ir/browse.php?a_code=A-10-1112-5&slc_lang=en&sid=1 Razieh Talebi nazi.talebi@yahoo.com 100319475328460011545 100319475328460011545 No Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Mahnaz Modanloo modanloo.mahnaz@goums.ac.ir 100319475328460011546 100319475328460011546 No Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran Fatemeh Heydari 100319475328460011547 100319475328460011547 No Children and Neonatal Health Research Center, Golestan University of Medical Sciences, Iran Neda Mehrdad neda1963@yahoo.com 100319475328460011548 100319475328460011548 No Endocrinology and Metabolism Research Center, Clinical Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran Abbasali Keshtkar abkeshtkar@gmail.com 100319475328460011549 100319475328460011549 No Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Homeira khoddam khoddam@goums.ac.ir 100319475328460011550 100319475328460011550 Yes Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran